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With 14 teams in the 2025 NCAA Tournament bracket, SEC vs. SEC was bound to happen. In the 2025 NCAA bracket Sweet 16, No. 2 Tennessee will face No. 3 Kentucky, the third time these rivals have met this season after the Wildcats took the first two. However, that isn't the only 2025 March Madness Sweet 16 contest that's a rematch, as No. 1 Duke vs. No. 4 Arizona will take place four months after Cooper Flagg and the Blue Devils went on the road and knocked off Arizona by double-digits.

How much should the results of those first matchups affect your March Madness Sweet 16 picks? Will the prior winners of these matchups complete the sweeps in the Sweet 16? Before locking in any March Madness predictions, be sure to see the 2025 NCAA Tournament bracket picks from the proven computer model at SportsLine.

SportsLine's proven projection model has simulated every game in the tournament 10,000 times. It has absolutely crushed its March Madness picks recently, beating over 91% of all CBS Sports brackets in four of the past six tournaments. The model nailed 13 of the 16 teams in the Sweet 16, and all four of its Final Four teams are still in the field.  It knows how to spot an upset as well. The same model has produced brackets that have nailed 25 first-round upsets by double-digit seeds since its inception in 2016.

There's no reason to rely on luck when there's proven technology to help you dominate your 2025 March Madness picks. Now, with the remainder of the 2025 NCAA bracket revealed, the model is simulating the matchups and its results are in. You can only see it over at SportsLine.

Top 2025 NCAA Tournament Sweet 16 picks

One of the Sweet 16 picks from the model: No. 2 seed Tennessee, despite losing to Kentucky twice this season, beats the Wildcats on Friday. Beating a team three times in one season is one of the hardest things to do, and that's especially the case when you're trying to knock off a Vols squad when missing one of your best players. That's what Kentucky coach Mark Pope is facing as senior Jaxson Robinson, whose 13 points per game are second-most on UK, is out for the season (wrist). Robinson starred in one of Kentucky's earlier wins over Tennessee, scoring 17 points in a January road victory.

His loss has been felt on both ends of the court as Kentucky is averaging three points fewer since he left the lineup, while the Cats are also giving up three more points per game. Meanwhile, Tennessee has the type of balance only shared by the tourney's top seeds. UT is one of five teams that rank in the top 20 in both offensive and defensive efficiency, per KenPom, with the other four being all of the No. 1 seeds. The model has the Vols' third-ranked defense holding UK to 11 points under its season average as Tennessee advances to its second straight Elite Eight. You can see the model's 2025 NCAA bracket picks here.

How to make 2025 NCAA bracket predictions

SportsLine's model also says the Final Four will feature something that hasn't happened in almost 20 years. With the model's track record of calling bracket-busting upsets, you'll want to see which teams it's picking this year before locking in any 2025 NCAA bracket picks.

So what's the optimal NCAA Tournament 2025 bracket, and what historic Final Four does the model predict? Visit SportsLine now to see which teams you can back with confidence, all from the model that has called 25 first-round upsets by double-digit seeds and nailed 13 Sweet 16 teams this year.